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YDL223C is an AMPA receptor potentiator that induces production of brain-derived neurotrophic factor (BDNF) and exhibits little agonistic effect in primary neurons. YDL223C binds to ligand-binding domain of AMPA-R in glutamate dependent manner.
YDL223C bound to the ligand-binding domain (LBD) of AMPA-R in a...
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